| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature
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| Autores: |
Otero,Luize
Souza,Daiane Correa de
Tavares,Rita de Cássia
Gomes,Bernadete Evangelho
Padilha,Telma França
Bouzas,Luiz Fernando
Fernandez,Teresa de Souza
Abdelhay,Eliana
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| Data: |
2012-01-01
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| Ano: |
2012
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| Palavras-chave: |
Monosomy 7
Donor cell leukemia
Bone marrow transplantation
Severe aplastic anemia
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| Resumo: |
Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000500004
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572012005000056
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.35 n.4 2012
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| Direitos: |
info:eu-repo/semantics/openAccess
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